Commentary: Vascularization and perfusion of engineered tissues
نویسندگان
چکیده
منابع مشابه
Vascularization--the conduit to viable engineered tissues.
Long-term viability of thick three-dimensional engineered tissue constructs is a major challenge. Addressing it requires development of vessel-like network that will allow the survival of the construct in vitro and its integration in vivo owing to improved vascularization after implantation. Resulting from work of various research groups, several approaches were developed aiming engineered tiss...
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Recent advances in medicine and healthcare allow people to live longer, increasing the need for the number of organ transplants. However, the number of organ donors has not been able to meet the demand, resulting in an organ shortage. The field of tissue engineering has emerged to produce organs to overcome this limitation. While tissue engineering of connective tissues such as skin and blood v...
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In this paper, we present a dynamic Bayesian network (DBN) approach to modeling vascularization in engineered tissues. Injuries and diseases can cause significant tissue loss to the degree where the body is unable to heal itself. Tissue engineering aims to replace the lost tissue through use of stem cells and biomaterials. For tissue cells to multiply and migrate, they need to be close to blood...
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Vascularization is critical for the survival of engineered tissues in vitro and in vivo. In vivo, angiogenesis involves endothelial cell proliferation and sprouting followed by connection of extended cellular processes and subsequent lumen propagation through vacuole fusion. We mimicked this process in engineering an organized capillary network anchored by an artery and a vein. The network was ...
متن کاملPerfusion systems that minimize vascular volume fraction in engineered tissues.
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2020
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2019.10.119